For instance, producing endogens synthesis from sun light or digestive route (exogenous route), particularly most of the herbivorous mammals can synthesize vitamin D from 7-Dehydrocholesterol (7-DHC) under the sun light exposure 1, 2, 3, 4, 5, since most of the herbivores, bovines depend on sunlight to synthesize 25-Hydroxyvitamin D ( 25D 3). There are different sources of vitamin D in mammals. Therefore, it is concluded that the variation of 25D 3 in plasma, after injection of Cholecalciferol, depends on its basic level at the time of injection. Moreover, the injection of Cholecalciferol could not significantly increase the 25D 3 concentration in the group A that had a sufficient basis 25D 3 concentration. However, this injection enriches the 25D 3 to sufficient value after two weeks if the basis 25D 3 of plasma is insufficient, i.e. Cholecalciferol injection could not immediately increase the 25D 3 in the groups C and A. The data collected from the two groups C and D showed that sun deprivation without any vitamin D supplementation, could rapidly and severely deplete the plasma from 25D 3. After Cholecalciferol injection, the effects of basis 25D 3 concentration on the details of variation and fate of plasma concentration of 25D 3 were investigated. At this time, groups A and C received the intermediate dose of (11,000 IU/kg) Cholecalciferol intramuscularly (IM). All groups had a different basic concentration (25D 3) on the day 21 of the experiment. The interference of the digestive system in supplying vitamin D was minimized through dietary. Groups A and B were unconstrained to choose sun to expose or shadow in a semi-roofed place, but groups C and D were restricted to the completely dark barn. To do this, the calves were divided into four groups. Furthermore, the effect of optional sun exposure/deprivation and Cholecalciferol injection on the 25D 3 concentration variations was assayed. To do this, twenty calves of 3 to 4 months old were chosen for the farm with semi-industrial elements. Besides, an attempt was made to clarify the time that 25D 3 reaches the sufficient concentration after injection in different treatment groups. In the same line, the present study, designed to induce the different basis 25D 3 concentration in treatment groups, aimed at investigating the effect of Cholecalciferol intramuscularly injection with the intermediate dose (11,000 IU/kg) on the calves' plasma 25D 3 with different basis 25D 3. On the other hand, it seems that the basis 25D 3 concentration can influence or shift the 25D 3 metabolism at the injection time. However, to our knowledge, the certain dose of Cholecalciferol injection for rapid 25D 3 plasma enrichment has not been verified. In such a condition, injection of Cholecalciferol has been recommended. Because of the critical effect of vitamin D on the immune and endocrine systems, the plasma must be enriched with 25D 3 in a short period of time. breeding systems, solar radiation cannot reach or penetrate into the skin and thus causes the 25D 3 deficiency. Sun exposure in bovines is believed to be the most important route of 25D 3 synthesis in suitable latitudes.
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